Item #	Code #	Code Type	Long Code Descriptor	
"CPT codes, descriptions and other data only are copyright 2017 American Medical Association. All Rights Reserved.
  Applicable FARS/HHSARS apply. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.


Corrections to Code list:  1)  Item #22 code 0037U deleted; 2) Item #71 Code number 8X010 (PLCG2 (phospholipase C gamma 2) (eg, chronic lymphocytic leukemia) gene analysis, common variants (eg, R665W, S707F, L845F) corrected to 81X10 (PLCG2 (phospholipase C gamma 2) (eg, chronic lymphocytic leukemia) gene analysis, common variants (eg, R665W, S707F, L845F)."				
1	81334	Reconsider 	"RUNX1 (runt related transcription factor 1) (eg, acute myeloid leukemia, familial platelet disorder with associated myeloid malignancy), gene analysis, targeted sequence analysis (eg, exons 3-8)."	
2	81326	Reconsider 	"PMP22 (peripheral myelin protein 22) (eg, Charcot-Marie-Tooth, hereditary neuropathy with liability to pressure palsies) gene analysis; known familial variant."	
3	0018U 	New--Proprietary Laboratory Analyses	"Oncology (thyroid), microRNA profiling by RT-PCR of 10 microRNA sequences, utilizing fine needle aspirate, algorithm reported as a positive or negative result for moderate to high risk of malignancy A3."	
4	0019U 	New--Proprietary Laboratory Analyses	"Oncology, RNA, gene expression by whole transcriptome sequencing, formalin-fixed paraffin embedded tissue or fresh frozen tissue, predictive algorithm reported as potential targets for therapeutic agents."	
5	0020U 	New--Proprietary Laboratory Analyses	"Drug test(s), presumptive, with definitive confirmation of positive results, any number of drug classes, urine, with specimen verification including DNA authentication in comparison to buccal DNA, per date of service."	
6	0021U 	New--Proprietary Laboratory Analyses	"Oncology (prostate), detection of 8 autoantibodies (ARF 6, NKX3-1, 5-UTR-BMI1, CEP 164, 3-UTR-Ropporin, Desmocollin, AURKAIP-1, CSNK2A2), multiplexed immunoassay and flow cytometry serum, algorithm reported as risk score."	
7	0022U	New--Proprietary Laboratory Analyses	"Targeted genomic sequence analysis panel, non-small cell lung neoplasia, DNA and RNA analysis, 23 genes, interrogation for sequence variants and rearrangements, reported as presence/absence of variants and associated therapy(ies) to consider."	
8	0023U 	New--Proprietary Laboratory Analyses	"Oncology (acute myelogenous leukemia), DNA, genotyping of internal tandem duplication, p.D835, p.I836, using mononuclear cells, reported as detection or non-detection of FLT3 mutation and indication for or against the use of midostaurin."	
9	0024U	New--Proprietary Laboratory Analyses	"Glycosylated acute phase proteins (GlycA), nuclear magnetic resonance spectroscopy, quantitative."	
10	0025U	New--Proprietary Laboratory Analyses	"Tenofovir, by liquid chromatography with tandem mass spectrometry (LC-MS/MS), urine, quantitative."	
11	0026U	New--Proprietary Laboratory Analyses	"Oncology (thyroid), DNA and mRNA of 112 genes, next-generation sequencing, fine needle aspirate of thyroid nodule, algorithmic analysis reported as a categorical result (""Positive, high probability of malignancy"" or ""Negative, low probability of malignancy"")."	
12	0027U	New--Proprietary Laboratory Analyses	"JAK2 (Janus kinase 2) (eg, myeloproliferative disorder) gene analysis, targeted sequence analysis exons 12-15."	
13	0028U	New--Proprietary Laboratory Analyses	"CYP2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6) (eg, drug metabolism) gene analysis, copy number variants, common variants with reflex to targeted sequence analysis."	
14	0029U	New--Proprietary Laboratory Analyses	"Drug metabolism (adverse drug reactions and drug response), targeted sequence analysis (ie, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, SLCO1B1, VKORC1 and rs12777823)."	
15	0030U	New--Proprietary Laboratory Analyses	"Drug metabolism (warfarin drug response), targeted sequence analysis (ie, CYP2C9, CYP4F2, VKORC1, rs12777823)."	
16	0031U	New--Proprietary Laboratory Analyses	"CYP1A2 (cytochrome P450 family 1, subfamily A, member 2)(eg, drug metabolism) gene analysis, common variants (ie, *1F, *1K, *6, *7)."	
17	0032U	New--Proprietary Laboratory Analyses	"COMT (catechol-O-methyltransferase)(drug metabolism) gene analysis, c.472G>A (rs4680) variant."	
18	0033U	New--Proprietary Laboratory Analyses	"HTR2A (5-hydroxytryptamine receptor 2A), HTR2C (5-hydroxytryptamine receptor 2C) (eg, citalopram metabolism) gene analysis, common variants (ie, HTR2A rs7997012 [c.614-2211T>C], HTR2C rs3813929 [c.-759C>T] and rs1414334 [c.551-3008C>G])."	
19	0034U	New--Proprietary Laboratory Analyses	"TPMT (thiopurine S-methyltransferase), NUDT15 (nudix hydroxylase 15)(eg, thiopurine metabolism), gene analysis, common variants (ie, TPMT *2, *3A, *3B, *3C, *4, *5, *6, *8, *12; NUDT15 *3, *4, *5)."	
20	0035U	New--Proprietary Laboratory Analyses	"Neurology (prion disease), cerebrospinal fluid, detection of prion protein by quaking-induced conformational conversion, qualitative."	
21	0036U	New--Proprietary Laboratory Analyses	"Exome (ie, somatic mutations), paired formalin-fixed paraffin-embedded tumor tissue and normal specimen, sequence analyses."	
22	0037U	New--Proprietary Laboratory Analyses	"Targeted genomic sequence analysis, solid organ neoplasm, DNA analysis of 324 genes, interrogation for sequence variants, gene copy number amplifications, gene rearrangements, microsatellite instability and tumor mutational burden."	
23	0038U	New--Proprietary Laboratory Analyses	"Vitamin D, 25 hydroxy D2 and D3, by LC-MS/MS, serum microsample, quantitative."	
24	0039U	New--Proprietary Laboratory Analyses	"Deoxyribonucleic acid (DNA) antibody, double stranded, high avidity."	
25	0040U	New--Proprietary Laboratory Analyses	"BCR/ABL1 (t(9;22)) (eg, chronic myelogenous leukemia) translocation analysis, major breakpoint, quantitative."	
26	0041U	New--Proprietary Laboratory Analyses	"Borrelia burgdorferi, antibody detection of 5 recombinant protein groups, by immunoblot, IgM."	
27	0042U	New--Proprietary Laboratory Analyses	"Borrelia burgdorferi, antibody detection of 12 recombinant protein groups, by immunoblot, IgG."	
28	0043U	New--Proprietary Laboratory Analyses	"Tick-borne relapsing fever Borrelia group, antibody detection to 4 recombinant protein groups, by immunoblot, IgM."	
29	0044U	New--Proprietary Laboratory Analyses	"Tick-borne relapsing fever Borrelia group, antibody detection to 4 recombinant protein groups, by immunoblot, IgG."	
30	0011M	New--Multianalyte Assays with Algorithmic Analyses	"Oncology, prostate cancer, mRNA expression assay of 12 genes (10 content and 2 housekeeping), RT-PCR test utilizing blood plasma and/or urine, algorithms to predict high-grade prostate cancer risk"	
31	0012M	New--Multianalyte Assays with Algorithmic Analyses	"Oncology (urothelial), mRNA, gene expression profiling by real-time quantitative PCR of five genes (MDK, HOXA13, CDC2 [CDK1], IGFBP5, and CXCR2), utilizing urine, algorithm reported as a risk score for having urothelial carcinoma                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              "	
32	0013M	New--Multianalyte Assays with Algorithmic Analyses	"Oncology (urothelial), mRNA, gene expression profiling by real-time quantitative PCR of five genes (MDK, HOXA13, CDC2 [CDK1], IGFBP5, and CXCR2), utilizing urine, algorithm reported as a risk score for having recurrent urothelial carcinoma"	
33	8X001	New--Molecular Pathology	"AFF2 (AF4/FMR2 family, member 2 [FMR2]) (eg, fragile X mental retardation 2 [FRAXE]) gene analysis; evaluation to detect abnormal (eg, expanded) alleles"	
34	8X002	New--Molecular Pathology	"AFF2 (AF4/FMR2 family, member 2 [FMR2]) (eg, fragile X mental retardation 2 [FRAXE]) gene analysis; characterization of alleles (eg, expanded size and methylation status)"	
35	8X003	New--Molecular Pathology	"AR (androgen receptor) (eg, spinal and bulbar muscular atrophy, Kennedy disease, X chromosome inactivation) gene analysis; characterization of alleles (eg, expanded size or methylation status)"	
36	8X004	New--Molecular Pathology	"AR (androgen receptor) (eg, spinal and bulbar muscular atrophy, Kennedy disease, X chromosome inactivation) gene analysis; full gene sequence"	
37	8X005	New--Molecular Pathology	"AR (androgen receptor) (eg, spinal and bulbar muscular atrophy, Kennedy disease, X chromosome inactivation) gene analysis; known familial variant"	
38	8X006	New--Molecular Pathology	"ATN1 (atrophin 1) (eg, dentatorubral-pallidoluysian atrophy) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
39	8X007	New--Molecular Pathology	"ATXN1 (ataxin 1) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
40	8X009	New--Molecular Pathology	"ATXN2 (ataxin 2) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
41	8X010	New--Molecular Pathology	"ATXN3 (ataxin 3) (eg, spinocerebellar ataxia, Machado-Joseph disease) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
42	8X011	New--Molecular Pathology	"ATXN7 (ataxin 7) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
43	8X012	New--Molecular Pathology	"ATXN8OS (ATXN8 opposite strand [non-protein coding]) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
44	8X008	New--Molecular Pathology	"ATXN10 (ataxin 10) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
45	81X78	New--Molecular Pathology	"BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; full sequence analysis"	
46	81X79	New--Molecular Pathology	"BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; full duplication/deletion analysis (ie, detection of large gene rearrangements)"	
47	81X81	New--Molecular Pathology	"BRCA1 (BRCA1, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; full sequence analysis"	
48	81X82	New--Molecular Pathology	"BRCA1 (BRCA1, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; full duplication/deletion analysis (ie, detection of large gene rearrangements)"	
49	81X83	New--Molecular Pathology	"BRCA2 (BRCA2, DNA repair associated)(eg, hereditary breast and ovarian cancer) gene analysis; full duplication/deletion analysis (ie, detection of large gene rearrangements)"	
50	81X09	New--Molecular Pathology	"BTK (Bruton's tyrosine kinase) (eg, chronic lymphocytic leukemia) gene analysis, common variants (eg, C481S, C481R, C481F)"	
51	8X013	New--Molecular Pathology	"CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene analysis; evaluation to detect abnormal (eg, expanded) alleles"	
52	8X014	New--Molecular Pathology	"CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene analysis; full gene sequence"	
53	8X015	New--Molecular Pathology	"CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene analysis; known familial variant"	
54	8X016	New--Molecular Pathology	"CNBP (CCHC-type zinc finger nucleic acid binding protein) (eg, myotonic dystrophy type 2) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
55	8X017	New--Molecular Pathology	"CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; evaluation to detect abnormal (eg, expanded) alleles"	
56	8X018	New--Molecular Pathology	"CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; full gene sequence"	
57	8X019	New--Molecular Pathology	"CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; known familial variant(s)"	
58	8X020	New--Molecular Pathology	"DMPK (DM1 protein kinase) (eg, myotonic dystrophy type 1) gene analysis; evaluation to detect abnormal (expanded) alleles"	
59	8X021	New--Molecular Pathology	"DMPK (DM1 protein kinase) (eg, myotonic dystrophy type 1) gene analysis; characterization of alleles (eg, expanded size)"	
60	81X07	New--Molecular Pathology	"EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) (eg, myelodysplastic syndrome, myeloproliferative neoplasms) gene analysis, full gene sequence"	
61	81X08	New--Molecular Pathology	"EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) (eg, diffuse large B-cell lymphoma) gene analysis, common variant(s) (eg, codon 646)"	
62	8X022	New--Molecular Pathology	"FXN (frataxin) (eg, Friedreich ataxia) gene analysis; evaluation to detect abnormal (expanded) alleles"	
63	8X023	New--Molecular Pathology	"FXN (frataxin) (eg, Friedreich ataxia) gene analysis; characterization of alleles (eg, expanded size)"	
64	8X024	New--Molecular Pathology	"FXN (frataxin) (eg, Friedreich ataxia) gene analysis; full gene sequence"	
65	8X025	New--Molecular Pathology	"FXN (frataxin) (eg, Friedreich ataxia) gene analysis; known familial variant(s)"	
66	8X026	New--Molecular Pathology	"HTT (huntingtin) (eg, Huntington disease) gene analysis; evaluation to detect abnormal (eg, expanded) alleles"	
67	8X027	New--Molecular Pathology	"HTT (huntingtin) (eg, Huntington disease) gene analysis; characterization of alleles (eg, expanded size)"	
68	81X11	New--Molecular Pathology	"MYD88 (myeloid differentiation primary response 88) (eg, Waldenstroms macroglobulinemia, lymphoplasmacytic leukemia) gene analysis, p.Leu265Pro (L265P) variant"	
69	8X000	New--Molecular Pathology	"NUDT15 (nudix hydrolase 15) (eg, drug metabolism) gene analysis, common variant(s) (eg, *2, *3, *4, *5, *6)"	
70	8X028	New--Molecular Pathology	"PABPN1 (poly[A] binding protein nuclear 1) (eg, oculopharyngeal muscular dystrophy) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
71	81X10  (previously 8X010)	New--Molecular Pathology	"PLCG2 (phospholipase C gamma 2) (eg, chronic lymphocytic leukemia) gene analysis, common variants (eg, R665W, S707F, L845F)"	
72	8X035	New--Molecular Pathology	"PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
73	8X032	New--Molecular Pathology	"SMN1 (survival of motor neuron 1, telomeric) (eg, spinal muscular atrophy) gene analysis; dosage/deletion analysis, includes SMN2 (survival of motor neuron 2, centromeric) analysis, if performed"	
74	8X033	New--Molecular Pathology	"SMN1 (survival of motor neuron 1, telomeric) (eg, spinal muscular atrophy) gene analysis; full gene sequence"	
75	8X034	New--Molecular Pathology	"SMN1 (survival of motor neuron 1, telomeric) (eg, spinal muscular atrophy) gene analysis; known familial sequence variant(s)"	
76	8X036	New--Molecular Pathology	"TBP (TATA box binding protein) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles"	
77	80X00	New--Molecular Pathology	"TERT (telomerase reverse transcriptase) (eg, thyroid carcinoma, glioblastoma multiforme) gene analysis, targeted sequence analysis (eg, promoter region)"	
78	813X0	New--Molecular Pathology	"TGFBI (transforming growth factor beta-induced) (eg, corneal dystrophy) gene analysis, common variants (eg, R124H, R124C, R124L, R555W, R555Q)"	
79	81X43	New--Genomic Sequencing Procedures and Other Molecular Multianalyte Assays	"Genetic testing for severe inherited conditions (eg, cystic fibrosis, Ashkenazi Jewish disorders [eg, Bloom syndrome, Canavan disease, Fanconi anemia type C, mucolipidosis type VI, Gaucher disease, Tay-Sachs disease], beta hemoglobinopathies, phenylketonuria, galactosemia), genomic sequence analysis panel, must include sequencing of at least 15 genes (eg, ACADM, ARSA, ASPA, ATP7B, BCKDHA, BCKDHB, BLM, CFTR, DHCR7, FANCC, G6PC, GAA, GALT, GBA, GBE1, HBB, HEXA, IKBKAP, MCOLN1, PAH)"	
80	816X0	New--Multianalyte Assays with Algorithmic Analyses	"Oncology (breast), mRNA, gene expression profiling by real-time RT-PCR of 11 genes (7 content and 4 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithms reported as percentage risk for metastatic recurrence and likelihood of benefit from extended endocrine therapy"	
81	80X01	New--Chemistry	Dihydrotestosterone (DHT)	
82	"815X0
"	New--Multianalyte Assays with Algorithmic Analyses	"Infectious disease, chronic Hepatitis C Virus (HCV) infection, six biochemical assays (ALT, A2-macroglobulin, apolipoprotein A-1, total bilirubin, GGT, and haptoglobin) utilizing serum, prognostic algorithm reported as scores for fibrosis and necroinflammatory activity in liver"	
83	8372X	New--Chemistry	"Lipoprotein, direct measurement; small dense LDL cholesterol"	
84	0045U	New--Proprietary Laboratory Analyses	"Oncology (breast ductal carcinoma in situ), mRNA, gene expression profiling by real-time RT-PCR of 12 genes (7 content and 5 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as recurrence score"	
85	0046U	New--Proprietary Laboratory Analyses	"FLT3 (fms-related tyrosine kinase 3) (eg, acute myeloid leukemia) internal tandem duplication (ITD) variants, quantitative"	
86	0047U	New--Proprietary Laboratory Analyses	"Oncology (prostate), mRNA, gene expression profiling by real-time RT-PCR of 17 genes (12 content and 5 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as a risk score "	
87	0048U	New--Proprietary Laboratory Analyses	"Oncology (solid organ neoplasia), DNA, targeted sequencing of protein-coding exons of 468 cancer-associated genes, including interrogation for somatic mutations and microsatellite instability, matched with normal specimens, utilizing formalin-fixed paraffin-embedded tumor tissue, report of clinically significant mutation(s)
"	
88	0049U	New--Proprietary Laboratory Analyses	"NPM1 (nucleophosmin) (eg, acute myeloid leukemia) gene analysis, quantitative"	
89	0050U	New--Proprietary Laboratory Analyses	"Targeted genomic sequence analysis panel, acute myelogenous leukemia, DNA analysis, 194 genes, interrogation for sequence variants, copy number variants or rearrangements
 
"	
90	0051U	New--Proprietary Laboratory Analyses	"Prescription drug monitoring, evaluation of drugs present by LC-MS/MS, urine, 31 drug panel, reported as quantitative results, detected or not detected, per date of service"	
91	0052U	New--Proprietary Laboratory Analyses	"Lipoprotein, blood, high resolution fractionation and quantitation of lipoproteins, including all five major lipoprotein classes and subclasses of HDL, LDL, and VLDL by vertical auto profile ultracentrifugation"	
92	0053U	New--Proprietary Laboratory Analyses	"Oncology (prostate cancer), FISH analysis of 4 genes (ASAP1, HDAC9, CHD1 and PTEN), needle biopsy specimen, algorithm reported as probability of higher tumor grade"	
93	0054U	New--Proprietary Laboratory Analyses	"Prescription drug monitoring, 14 or more classes of drugs and substances, definitive tandem mass spectrometry with chromatography, capillary blood, quantitative report with therapeutic and toxic ranges, including steady-state range for the prescribed dose when detected, per date of service"	
94	0055U	New--Proprietary Laboratory Analyses	"Cardiology (heart transplant), cell-free DNA, PCR assay of 96 DNA target sequences (94 single nucleotide polymorphism targets and two control targets), plasma"	
95	0056U	New--Proprietary Laboratory Analyses	"Hematology (acute myelogenous leukemia), DNA, whole genome next-generation sequencing to detect gene rearrangement(s), blood or bone marrow, report of specific gene rearrangement(s)"	
96	0057U	New--Proprietary Laboratory Analyses	"Oncology (solid organ neoplasia), mRNA, gene expression profiling by massively parallel sequencing for analysis of 51 genes, utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as a normalized percentile rank"	
97	0058U	New--Proprietary Laboratory Analyses	"Oncology (Merkel cell carcinoma), detection of antibodies to the Merkel cell polyoma virus oncoprotein (small T antigen), serum, quantitative"	
98	0059U	New--Proprietary Laboratory Analyses	"Oncology (Merkel cell carcinoma), detection of antibodies to the Merkel cell polyoma virus capsid protein (VP1), serum, reported as positive or negative"	
99	0060U	New--Proprietary Laboratory Analyses	"Twin zygosity, genomic targeted sequence analysis of chromosome 2, using circulating cell-free fetal DNA in maternal blood "	
100	0061U	New--Proprietary Laboratory Analyses	"Transcutaneous measurement of five  biomarkers (tissue oxygenation [StO2], oxyhemoglobin [ctHbO2], deoxyhemoglobin [ctHbR], papillary and reticular dermal hemoglobin concentrations [ctHb1 and ctHb2]), using spatial frequency domain imaging (SFDI) and multi-spectral analysis"	
