SUPERSEDED LCD Reference Article Billing and Coding Article

Billing and Coding: Biomarkers Overview

A56541

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Draft Articles are works in progress and not necessarily a reflection of the current billing and coding practices. Revisions to codes are carefully and thoroughly reviewed and are not intended to change the original intent of the LCD.
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General Information

Source Article ID
N/A
Article ID
A56541
Original ICD-9 Article ID
Not Applicable
Article Title
Billing and Coding: Biomarkers Overview
Article Type
Billing and Coding
Original Effective Date
05/30/2019
Revision Effective Date
08/03/2022
Revision Ending Date
12/31/2023
Retirement Date
N/A

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CMS National Coverage Policy

Social Security Act (Title XVIII) Standard References:

  • Title XVIII of the Social Security Act, Section 1833(e) states that no payment shall be made to any provider of services or other person under this part unless there has been furnished such information as may be necessary in order to determine the amounts due such provider or other person under this part for the period with respect to which the amounts are being paid or for any prior period.

Article Guidance

Article Text

This Billing and Coding Article provides billing and coding guidance for Local Coverage Determination (LCD) L35062 Biomarkers Overview. Please refer to the LCD for reasonable and necessary requirements.

Coding Guidance

Notice: It is not appropriate to bill Medicare for services that are not covered (as described by the entire LCD) as if they are covered. When billing for non-covered services, use the appropriate modifier.

It is the expectation, that when reporting ICD-10 codes the code representing the highest level of specificity documented in the medical record should be reported and unspecified codes should only be used when they are the code that most accurately reflects what is known about the patient's condition at the time of the encounter.

Utilization Parameters

CPT code 81490, Autoimmune (rheumatoid arthritis), is limited to two services per rolling year per beneficiary.

Documentation Requirements

  1. All documentation must be maintained in the patient's medical record and made available to the contractor upon request.
  2. Every page of the record must be legible and include appropriate patient identification information (e.g., complete name, dates of service[s]). The documentation must include the legible signature of the physician or non-physician practitioner responsible for and providing the care to the patient.
  3. The submitted medical record must support the use of the selected ICD-10-CM code(s). The submitted CPT/HCPCS code must describe the service performed.

Response To Comments

Number Comment Response
1
N/A

Coding Information

Bill Type Codes

Code Description

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Revenue Codes

Code Description

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CPT/HCPCS Codes

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CPT/HCPCS Modifiers

Group 1

Group 1 Paragraph

N/A

Group 1 Codes

N/A

N/A

ICD-10-CM Codes that Support Medical Necessity

Group 1

(111 Codes)
Group 1 Paragraph

It is the provider’s responsibility to select codes carried out to the highest level of specificity and selected from the ICD-10-CM code book appropriate to the year in which the service is rendered for the claim(s) submitted.

The following ICD-10-CM codes support medical necessity and provide coverage for CPT codes: 81240 and 81241.

Group 1 Codes
Code Description
I81 Portal vein thrombosis
I82.0 Budd-Chiari syndrome
I82.1 Thrombophlebitis migrans
I82.210 Acute embolism and thrombosis of superior vena cava
I82.211 Chronic embolism and thrombosis of superior vena cava
I82.220 Acute embolism and thrombosis of inferior vena cava
I82.221 Chronic embolism and thrombosis of inferior vena cava
I82.290 Acute embolism and thrombosis of other thoracic veins
I82.291 Chronic embolism and thrombosis of other thoracic veins
I82.3 Embolism and thrombosis of renal vein
I82.401 Acute embolism and thrombosis of unspecified deep veins of right lower extremity
I82.402 Acute embolism and thrombosis of unspecified deep veins of left lower extremity
I82.403 Acute embolism and thrombosis of unspecified deep veins of lower extremity, bilateral
I82.411 Acute embolism and thrombosis of right femoral vein
I82.412 Acute embolism and thrombosis of left femoral vein
I82.413 Acute embolism and thrombosis of femoral vein, bilateral
I82.421 Acute embolism and thrombosis of right iliac vein
I82.422 Acute embolism and thrombosis of left iliac vein
I82.423 Acute embolism and thrombosis of iliac vein, bilateral
I82.431 Acute embolism and thrombosis of right popliteal vein
I82.432 Acute embolism and thrombosis of left popliteal vein
I82.433 Acute embolism and thrombosis of popliteal vein, bilateral
I82.441 Acute embolism and thrombosis of right tibial vein
I82.442 Acute embolism and thrombosis of left tibial vein
I82.443 Acute embolism and thrombosis of tibial vein, bilateral
I82.451 Acute embolism and thrombosis of right peroneal vein
I82.452 Acute embolism and thrombosis of left peroneal vein
I82.453 Acute embolism and thrombosis of peroneal vein, bilateral
I82.461 Acute embolism and thrombosis of right calf muscular vein
I82.462 Acute embolism and thrombosis of left calf muscular vein
I82.463 Acute embolism and thrombosis of calf muscular vein, bilateral
I82.491 Acute embolism and thrombosis of other specified deep vein of right lower extremity
I82.492 Acute embolism and thrombosis of other specified deep vein of left lower extremity
I82.493 Acute embolism and thrombosis of other specified deep vein of lower extremity, bilateral
I82.4Y1 Acute embolism and thrombosis of unspecified deep veins of right proximal lower extremity
I82.4Y2 Acute embolism and thrombosis of unspecified deep veins of left proximal lower extremity
I82.4Y3 Acute embolism and thrombosis of unspecified deep veins of proximal lower extremity, bilateral
I82.4Z1 Acute embolism and thrombosis of unspecified deep veins of right distal lower extremity
I82.4Z2 Acute embolism and thrombosis of unspecified deep veins of left distal lower extremity
I82.4Z3 Acute embolism and thrombosis of unspecified deep veins of distal lower extremity, bilateral
I82.501 Chronic embolism and thrombosis of unspecified deep veins of right lower extremity
I82.502 Chronic embolism and thrombosis of unspecified deep veins of left lower extremity
I82.503 Chronic embolism and thrombosis of unspecified deep veins of lower extremity, bilateral
I82.511 Chronic embolism and thrombosis of right femoral vein
I82.512 Chronic embolism and thrombosis of left femoral vein
I82.513 Chronic embolism and thrombosis of femoral vein, bilateral
I82.521 Chronic embolism and thrombosis of right iliac vein
I82.522 Chronic embolism and thrombosis of left iliac vein
I82.523 Chronic embolism and thrombosis of iliac vein, bilateral
I82.531 Chronic embolism and thrombosis of right popliteal vein
I82.532 Chronic embolism and thrombosis of left popliteal vein
I82.533 Chronic embolism and thrombosis of popliteal vein, bilateral
I82.541 Chronic embolism and thrombosis of right tibial vein
I82.542 Chronic embolism and thrombosis of left tibial vein
I82.543 Chronic embolism and thrombosis of tibial vein, bilateral
I82.551 Chronic embolism and thrombosis of right peroneal vein
I82.552 Chronic embolism and thrombosis of left peroneal vein
I82.553 Chronic embolism and thrombosis of peroneal vein, bilateral
I82.561 Chronic embolism and thrombosis of right calf muscular vein
I82.562 Chronic embolism and thrombosis of left calf muscular vein
I82.563 Chronic embolism and thrombosis of calf muscular vein, bilateral
I82.591 Chronic embolism and thrombosis of other specified deep vein of right lower extremity
I82.592 Chronic embolism and thrombosis of other specified deep vein of left lower extremity
I82.593 Chronic embolism and thrombosis of other specified deep vein of lower extremity, bilateral
I82.5Y1 Chronic embolism and thrombosis of unspecified deep veins of right proximal lower extremity
I82.5Y2 Chronic embolism and thrombosis of unspecified deep veins of left proximal lower extremity
I82.5Y3 Chronic embolism and thrombosis of unspecified deep veins of proximal lower extremity, bilateral
I82.5Z1 Chronic embolism and thrombosis of unspecified deep veins of right distal lower extremity
I82.5Z2 Chronic embolism and thrombosis of unspecified deep veins of left distal lower extremity
I82.5Z3 Chronic embolism and thrombosis of unspecified deep veins of distal lower extremity, bilateral
I82.601 Acute embolism and thrombosis of unspecified veins of right upper extremity
I82.602 Acute embolism and thrombosis of unspecified veins of left upper extremity
I82.603 Acute embolism and thrombosis of unspecified veins of upper extremity, bilateral
I82.611 Acute embolism and thrombosis of superficial veins of right upper extremity
I82.612 Acute embolism and thrombosis of superficial veins of left upper extremity
I82.613 Acute embolism and thrombosis of superficial veins of upper extremity, bilateral
I82.621 Acute embolism and thrombosis of deep veins of right upper extremity
I82.622 Acute embolism and thrombosis of deep veins of left upper extremity
I82.623 Acute embolism and thrombosis of deep veins of upper extremity, bilateral
I82.701 Chronic embolism and thrombosis of unspecified veins of right upper extremity
I82.702 Chronic embolism and thrombosis of unspecified veins of left upper extremity
I82.703 Chronic embolism and thrombosis of unspecified veins of upper extremity, bilateral
I82.711 Chronic embolism and thrombosis of superficial veins of right upper extremity
I82.712 Chronic embolism and thrombosis of superficial veins of left upper extremity
I82.713 Chronic embolism and thrombosis of superficial veins of upper extremity, bilateral
I82.721 Chronic embolism and thrombosis of deep veins of right upper extremity
I82.722 Chronic embolism and thrombosis of deep veins of left upper extremity
I82.723 Chronic embolism and thrombosis of deep veins of upper extremity, bilateral
I82.A11 Acute embolism and thrombosis of right axillary vein
I82.A12 Acute embolism and thrombosis of left axillary vein
I82.A13 Acute embolism and thrombosis of axillary vein, bilateral
I82.A21 Chronic embolism and thrombosis of right axillary vein
I82.A22 Chronic embolism and thrombosis of left axillary vein
I82.A23 Chronic embolism and thrombosis of axillary vein, bilateral
I82.B11 Acute embolism and thrombosis of right subclavian vein
I82.B12 Acute embolism and thrombosis of left subclavian vein
I82.B13 Acute embolism and thrombosis of subclavian vein, bilateral
I82.B21 Chronic embolism and thrombosis of right subclavian vein
I82.B22 Chronic embolism and thrombosis of left subclavian vein
I82.B23 Chronic embolism and thrombosis of subclavian vein, bilateral
I82.C11 Acute embolism and thrombosis of right internal jugular vein
I82.C12 Acute embolism and thrombosis of left internal jugular vein
I82.C13 Acute embolism and thrombosis of internal jugular vein, bilateral
I82.C21 Chronic embolism and thrombosis of right internal jugular vein
I82.C22 Chronic embolism and thrombosis of left internal jugular vein
I82.C23 Chronic embolism and thrombosis of internal jugular vein, bilateral
I82.811 Embolism and thrombosis of superficial veins of right lower extremity
I82.812 Embolism and thrombosis of superficial veins of left lower extremity
I82.813 Embolism and thrombosis of superficial veins of lower extremities, bilateral
I82.890 Acute embolism and thrombosis of other specified veins
I82.91 Chronic embolism and thrombosis of unspecified vein

Group 2

(290 Codes)
Group 2 Paragraph

It is the provider’s responsibility to select codes carried out to the highest level of specificity and selected from the ICD-10-CM code book appropriate to the year in which the service is rendered for the claim(s) submitted.

The following ICD-10-CM codes support medical necessity and provide coverage for CPT code: 81490.

Group 2 Codes
Code Description
M05.00 Felty's syndrome, unspecified site
M05.011 Felty's syndrome, right shoulder
M05.012 Felty's syndrome, left shoulder
M05.019 Felty's syndrome, unspecified shoulder
M05.021 Felty's syndrome, right elbow
M05.022 Felty's syndrome, left elbow
M05.029 Felty's syndrome, unspecified elbow
M05.031 Felty's syndrome, right wrist
M05.032 Felty's syndrome, left wrist
M05.039 Felty's syndrome, unspecified wrist
M05.041 Felty's syndrome, right hand
M05.042 Felty's syndrome, left hand
M05.049 Felty's syndrome, unspecified hand
M05.051 Felty's syndrome, right hip
M05.052 Felty's syndrome, left hip
M05.059 Felty's syndrome, unspecified hip
M05.061 Felty's syndrome, right knee
M05.062 Felty's syndrome, left knee
M05.069 Felty's syndrome, unspecified knee
M05.071 Felty's syndrome, right ankle and foot
M05.072 Felty's syndrome, left ankle and foot
M05.079 Felty's syndrome, unspecified ankle and foot
M05.09 Felty's syndrome, multiple sites
M05.10 Rheumatoid lung disease with rheumatoid arthritis of unspecified site
M05.111 Rheumatoid lung disease with rheumatoid arthritis of right shoulder
M05.112 Rheumatoid lung disease with rheumatoid arthritis of left shoulder
M05.119 Rheumatoid lung disease with rheumatoid arthritis of unspecified shoulder
M05.121 Rheumatoid lung disease with rheumatoid arthritis of right elbow
M05.122 Rheumatoid lung disease with rheumatoid arthritis of left elbow
M05.129 Rheumatoid lung disease with rheumatoid arthritis of unspecified elbow
M05.131 Rheumatoid lung disease with rheumatoid arthritis of right wrist
M05.132 Rheumatoid lung disease with rheumatoid arthritis of left wrist
M05.139 Rheumatoid lung disease with rheumatoid arthritis of unspecified wrist
M05.141 Rheumatoid lung disease with rheumatoid arthritis of right hand
M05.142 Rheumatoid lung disease with rheumatoid arthritis of left hand
M05.149 Rheumatoid lung disease with rheumatoid arthritis of unspecified hand
M05.151 Rheumatoid lung disease with rheumatoid arthritis of right hip
M05.152 Rheumatoid lung disease with rheumatoid arthritis of left hip
M05.159 Rheumatoid lung disease with rheumatoid arthritis of unspecified hip
M05.161 Rheumatoid lung disease with rheumatoid arthritis of right knee
M05.162 Rheumatoid lung disease with rheumatoid arthritis of left knee
M05.169 Rheumatoid lung disease with rheumatoid arthritis of unspecified knee
M05.171 Rheumatoid lung disease with rheumatoid arthritis of right ankle and foot
M05.172 Rheumatoid lung disease with rheumatoid arthritis of left ankle and foot
M05.179 Rheumatoid lung disease with rheumatoid arthritis of unspecified ankle and foot
M05.19 Rheumatoid lung disease with rheumatoid arthritis of multiple sites
M05.20 Rheumatoid vasculitis with rheumatoid arthritis of unspecified site
M05.211 Rheumatoid vasculitis with rheumatoid arthritis of right shoulder
M05.212 Rheumatoid vasculitis with rheumatoid arthritis of left shoulder
M05.219 Rheumatoid vasculitis with rheumatoid arthritis of unspecified shoulder
M05.221 Rheumatoid vasculitis with rheumatoid arthritis of right elbow
M05.222 Rheumatoid vasculitis with rheumatoid arthritis of left elbow
M05.229 Rheumatoid vasculitis with rheumatoid arthritis of unspecified elbow
M05.231 Rheumatoid vasculitis with rheumatoid arthritis of right wrist
M05.232 Rheumatoid vasculitis with rheumatoid arthritis of left wrist
M05.239 Rheumatoid vasculitis with rheumatoid arthritis of unspecified wrist
M05.241 Rheumatoid vasculitis with rheumatoid arthritis of right hand
M05.242 Rheumatoid vasculitis with rheumatoid arthritis of left hand
M05.249 Rheumatoid vasculitis with rheumatoid arthritis of unspecified hand
M05.251 Rheumatoid vasculitis with rheumatoid arthritis of right hip
M05.252 Rheumatoid vasculitis with rheumatoid arthritis of left hip
M05.259 Rheumatoid vasculitis with rheumatoid arthritis of unspecified hip
M05.261 Rheumatoid vasculitis with rheumatoid arthritis of right knee
M05.262 Rheumatoid vasculitis with rheumatoid arthritis of left knee
M05.269 Rheumatoid vasculitis with rheumatoid arthritis of unspecified knee
M05.271 Rheumatoid vasculitis with rheumatoid arthritis of right ankle and foot
M05.272 Rheumatoid vasculitis with rheumatoid arthritis of left ankle and foot
M05.279 Rheumatoid vasculitis with rheumatoid arthritis of unspecified ankle and foot
M05.29 Rheumatoid vasculitis with rheumatoid arthritis of multiple sites
M05.30 Rheumatoid heart disease with rheumatoid arthritis of unspecified site
M05.311 Rheumatoid heart disease with rheumatoid arthritis of right shoulder
M05.312 Rheumatoid heart disease with rheumatoid arthritis of left shoulder
M05.319 Rheumatoid heart disease with rheumatoid arthritis of unspecified shoulder
M05.321 Rheumatoid heart disease with rheumatoid arthritis of right elbow
M05.322 Rheumatoid heart disease with rheumatoid arthritis of left elbow
M05.329 Rheumatoid heart disease with rheumatoid arthritis of unspecified elbow
M05.331 Rheumatoid heart disease with rheumatoid arthritis of right wrist
M05.332 Rheumatoid heart disease with rheumatoid arthritis of left wrist
M05.339 Rheumatoid heart disease with rheumatoid arthritis of unspecified wrist
M05.341 Rheumatoid heart disease with rheumatoid arthritis of right hand
M05.342 Rheumatoid heart disease with rheumatoid arthritis of left hand
M05.349 Rheumatoid heart disease with rheumatoid arthritis of unspecified hand
M05.351 Rheumatoid heart disease with rheumatoid arthritis of right hip
M05.352 Rheumatoid heart disease with rheumatoid arthritis of left hip
M05.359 Rheumatoid heart disease with rheumatoid arthritis of unspecified hip
M05.361 Rheumatoid heart disease with rheumatoid arthritis of right knee
M05.362 Rheumatoid heart disease with rheumatoid arthritis of left knee
M05.369 Rheumatoid heart disease with rheumatoid arthritis of unspecified knee
M05.371 Rheumatoid heart disease with rheumatoid arthritis of right ankle and foot
M05.372 Rheumatoid heart disease with rheumatoid arthritis of left ankle and foot
M05.379 Rheumatoid heart disease with rheumatoid arthritis of unspecified ankle and foot
M05.39 Rheumatoid heart disease with rheumatoid arthritis of multiple sites
M05.40 Rheumatoid myopathy with rheumatoid arthritis of unspecified site
M05.411 Rheumatoid myopathy with rheumatoid arthritis of right shoulder
M05.412 Rheumatoid myopathy with rheumatoid arthritis of left shoulder
M05.419 Rheumatoid myopathy with rheumatoid arthritis of unspecified shoulder
M05.421 Rheumatoid myopathy with rheumatoid arthritis of right elbow
M05.422 Rheumatoid myopathy with rheumatoid arthritis of left elbow
M05.429 Rheumatoid myopathy with rheumatoid arthritis of unspecified elbow
M05.431 Rheumatoid myopathy with rheumatoid arthritis of right wrist
M05.432 Rheumatoid myopathy with rheumatoid arthritis of left wrist
M05.439 Rheumatoid myopathy with rheumatoid arthritis of unspecified wrist
M05.441 Rheumatoid myopathy with rheumatoid arthritis of right hand
M05.442 Rheumatoid myopathy with rheumatoid arthritis of left hand
M05.449 Rheumatoid myopathy with rheumatoid arthritis of unspecified hand
M05.451 Rheumatoid myopathy with rheumatoid arthritis of right hip
M05.452 Rheumatoid myopathy with rheumatoid arthritis of left hip
M05.459 Rheumatoid myopathy with rheumatoid arthritis of unspecified hip
M05.461 Rheumatoid myopathy with rheumatoid arthritis of right knee
M05.462 Rheumatoid myopathy with rheumatoid arthritis of left knee
M05.469 Rheumatoid myopathy with rheumatoid arthritis of unspecified knee
M05.471 Rheumatoid myopathy with rheumatoid arthritis of right ankle and foot
M05.472 Rheumatoid myopathy with rheumatoid arthritis of left ankle and foot
M05.479 Rheumatoid myopathy with rheumatoid arthritis of unspecified ankle and foot
M05.49 Rheumatoid myopathy with rheumatoid arthritis of multiple sites
M05.50 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified site
M05.511 Rheumatoid polyneuropathy with rheumatoid arthritis of right shoulder
M05.512 Rheumatoid polyneuropathy with rheumatoid arthritis of left shoulder
M05.519 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified shoulder
M05.521 Rheumatoid polyneuropathy with rheumatoid arthritis of right elbow
M05.522 Rheumatoid polyneuropathy with rheumatoid arthritis of left elbow
M05.529 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified elbow
M05.531 Rheumatoid polyneuropathy with rheumatoid arthritis of right wrist
M05.532 Rheumatoid polyneuropathy with rheumatoid arthritis of left wrist
M05.539 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified wrist
M05.541 Rheumatoid polyneuropathy with rheumatoid arthritis of right hand
M05.542 Rheumatoid polyneuropathy with rheumatoid arthritis of left hand
M05.549 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified hand
M05.551 Rheumatoid polyneuropathy with rheumatoid arthritis of right hip
M05.552 Rheumatoid polyneuropathy with rheumatoid arthritis of left hip
M05.559 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified hip
M05.561 Rheumatoid polyneuropathy with rheumatoid arthritis of right knee
M05.562 Rheumatoid polyneuropathy with rheumatoid arthritis of left knee
M05.569 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified knee
M05.571 Rheumatoid polyneuropathy with rheumatoid arthritis of right ankle and foot
M05.572 Rheumatoid polyneuropathy with rheumatoid arthritis of left ankle and foot
M05.579 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified ankle and foot
M05.59 Rheumatoid polyneuropathy with rheumatoid arthritis of multiple sites
M05.60 Rheumatoid arthritis of unspecified site with involvement of other organs and systems
M05.611 Rheumatoid arthritis of right shoulder with involvement of other organs and systems
M05.612 Rheumatoid arthritis of left shoulder with involvement of other organs and systems
M05.619 Rheumatoid arthritis of unspecified shoulder with involvement of other organs and systems
M05.621 Rheumatoid arthritis of right elbow with involvement of other organs and systems
M05.622 Rheumatoid arthritis of left elbow with involvement of other organs and systems
M05.629 Rheumatoid arthritis of unspecified elbow with involvement of other organs and systems
M05.631 Rheumatoid arthritis of right wrist with involvement of other organs and systems
M05.632 Rheumatoid arthritis of left wrist with involvement of other organs and systems
M05.639 Rheumatoid arthritis of unspecified wrist with involvement of other organs and systems
M05.641 Rheumatoid arthritis of right hand with involvement of other organs and systems
M05.642 Rheumatoid arthritis of left hand with involvement of other organs and systems
M05.649 Rheumatoid arthritis of unspecified hand with involvement of other organs and systems
M05.651 Rheumatoid arthritis of right hip with involvement of other organs and systems
M05.652 Rheumatoid arthritis of left hip with involvement of other organs and systems
M05.659 Rheumatoid arthritis of unspecified hip with involvement of other organs and systems
M05.661 Rheumatoid arthritis of right knee with involvement of other organs and systems
M05.662 Rheumatoid arthritis of left knee with involvement of other organs and systems
M05.669 Rheumatoid arthritis of unspecified knee with involvement of other organs and systems
M05.671 Rheumatoid arthritis of right ankle and foot with involvement of other organs and systems
M05.672 Rheumatoid arthritis of left ankle and foot with involvement of other organs and systems
M05.679 Rheumatoid arthritis of unspecified ankle and foot with involvement of other organs and systems
M05.69 Rheumatoid arthritis of multiple sites with involvement of other organs and systems
M05.70 Rheumatoid arthritis with rheumatoid factor of unspecified site without organ or systems involvement
M05.711 Rheumatoid arthritis with rheumatoid factor of right shoulder without organ or systems involvement
M05.712 Rheumatoid arthritis with rheumatoid factor of left shoulder without organ or systems involvement
M05.719 Rheumatoid arthritis with rheumatoid factor of unspecified shoulder without organ or systems involvement
M05.721 Rheumatoid arthritis with rheumatoid factor of right elbow without organ or systems involvement
M05.722 Rheumatoid arthritis with rheumatoid factor of left elbow without organ or systems involvement
M05.729 Rheumatoid arthritis with rheumatoid factor of unspecified elbow without organ or systems involvement
M05.731 Rheumatoid arthritis with rheumatoid factor of right wrist without organ or systems involvement
M05.732 Rheumatoid arthritis with rheumatoid factor of left wrist without organ or systems involvement
M05.739 Rheumatoid arthritis with rheumatoid factor of unspecified wrist without organ or systems involvement
M05.741 Rheumatoid arthritis with rheumatoid factor of right hand without organ or systems involvement
M05.742 Rheumatoid arthritis with rheumatoid factor of left hand without organ or systems involvement
M05.749 Rheumatoid arthritis with rheumatoid factor of unspecified hand without organ or systems involvement
M05.751 Rheumatoid arthritis with rheumatoid factor of right hip without organ or systems involvement
M05.752 Rheumatoid arthritis with rheumatoid factor of left hip without organ or systems involvement
M05.759 Rheumatoid arthritis with rheumatoid factor of unspecified hip without organ or systems involvement
M05.761 Rheumatoid arthritis with rheumatoid factor of right knee without organ or systems involvement
M05.762 Rheumatoid arthritis with rheumatoid factor of left knee without organ or systems involvement
M05.769 Rheumatoid arthritis with rheumatoid factor of unspecified knee without organ or systems involvement
M05.771 Rheumatoid arthritis with rheumatoid factor of right ankle and foot without organ or systems involvement
M05.772 Rheumatoid arthritis with rheumatoid factor of left ankle and foot without organ or systems involvement
M05.779 Rheumatoid arthritis with rheumatoid factor of unspecified ankle and foot without organ or systems involvement
M05.79 Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement
M05.811 Other rheumatoid arthritis with rheumatoid factor of right shoulder
M05.812 Other rheumatoid arthritis with rheumatoid factor of left shoulder
M05.821 Other rheumatoid arthritis with rheumatoid factor of right elbow
M05.822 Other rheumatoid arthritis with rheumatoid factor of left elbow
M05.831 Other rheumatoid arthritis with rheumatoid factor of right wrist
M05.832 Other rheumatoid arthritis with rheumatoid factor of left wrist
M05.841 Other rheumatoid arthritis with rheumatoid factor of right hand
M05.842 Other rheumatoid arthritis with rheumatoid factor of left hand
M05.851 Other rheumatoid arthritis with rheumatoid factor of right hip
M05.852 Other rheumatoid arthritis with rheumatoid factor of left hip
M05.861 Other rheumatoid arthritis with rheumatoid factor of right knee
M05.862 Other rheumatoid arthritis with rheumatoid factor of left knee
M05.871 Other rheumatoid arthritis with rheumatoid factor of right ankle and foot
M05.872 Other rheumatoid arthritis with rheumatoid factor of left ankle and foot
M05.89 Other rheumatoid arthritis with rheumatoid factor of multiple sites
M05.9 Rheumatoid arthritis with rheumatoid factor, unspecified
M06.00 Rheumatoid arthritis without rheumatoid factor, unspecified site
M06.011 Rheumatoid arthritis without rheumatoid factor, right shoulder
M06.012 Rheumatoid arthritis without rheumatoid factor, left shoulder
M06.019 Rheumatoid arthritis without rheumatoid factor, unspecified shoulder
M06.021 Rheumatoid arthritis without rheumatoid factor, right elbow
M06.022 Rheumatoid arthritis without rheumatoid factor, left elbow
M06.029 Rheumatoid arthritis without rheumatoid factor, unspecified elbow
M06.031 Rheumatoid arthritis without rheumatoid factor, right wrist
M06.032 Rheumatoid arthritis without rheumatoid factor, left wrist
M06.039 Rheumatoid arthritis without rheumatoid factor, unspecified wrist
M06.041 Rheumatoid arthritis without rheumatoid factor, right hand
M06.042 Rheumatoid arthritis without rheumatoid factor, left hand
M06.049 Rheumatoid arthritis without rheumatoid factor, unspecified hand
M06.051 Rheumatoid arthritis without rheumatoid factor, right hip
M06.052 Rheumatoid arthritis without rheumatoid factor, left hip
M06.059 Rheumatoid arthritis without rheumatoid factor, unspecified hip
M06.061 Rheumatoid arthritis without rheumatoid factor, right knee
M06.062 Rheumatoid arthritis without rheumatoid factor, left knee
M06.069 Rheumatoid arthritis without rheumatoid factor, unspecified knee
M06.071 Rheumatoid arthritis without rheumatoid factor, right ankle and foot
M06.072 Rheumatoid arthritis without rheumatoid factor, left ankle and foot
M06.079 Rheumatoid arthritis without rheumatoid factor, unspecified ankle and foot
M06.08 Rheumatoid arthritis without rheumatoid factor, vertebrae
M06.09 Rheumatoid arthritis without rheumatoid factor, multiple sites
M06.1 Adult-onset Still's disease
M06.20 Rheumatoid bursitis, unspecified site
M06.211 Rheumatoid bursitis, right shoulder
M06.212 Rheumatoid bursitis, left shoulder
M06.219 Rheumatoid bursitis, unspecified shoulder
M06.221 Rheumatoid bursitis, right elbow
M06.222 Rheumatoid bursitis, left elbow
M06.229 Rheumatoid bursitis, unspecified elbow
M06.231 Rheumatoid bursitis, right wrist
M06.232 Rheumatoid bursitis, left wrist
M06.239 Rheumatoid bursitis, unspecified wrist
M06.241 Rheumatoid bursitis, right hand
M06.242 Rheumatoid bursitis, left hand
M06.249 Rheumatoid bursitis, unspecified hand
M06.251 Rheumatoid bursitis, right hip
M06.252 Rheumatoid bursitis, left hip
M06.259 Rheumatoid bursitis, unspecified hip
M06.261 Rheumatoid bursitis, right knee
M06.262 Rheumatoid bursitis, left knee
M06.269 Rheumatoid bursitis, unspecified knee
M06.271 Rheumatoid bursitis, right ankle and foot
M06.272 Rheumatoid bursitis, left ankle and foot
M06.279 Rheumatoid bursitis, unspecified ankle and foot
M06.28 Rheumatoid bursitis, vertebrae
M06.29 Rheumatoid bursitis, multiple sites
M06.30 Rheumatoid nodule, unspecified site
M06.311 Rheumatoid nodule, right shoulder
M06.312 Rheumatoid nodule, left shoulder
M06.319 Rheumatoid nodule, unspecified shoulder
M06.321 Rheumatoid nodule, right elbow
M06.322 Rheumatoid nodule, left elbow
M06.329 Rheumatoid nodule, unspecified elbow
M06.331 Rheumatoid nodule, right wrist
M06.332 Rheumatoid nodule, left wrist
M06.339 Rheumatoid nodule, unspecified wrist
M06.341 Rheumatoid nodule, right hand
M06.342 Rheumatoid nodule, left hand
M06.349 Rheumatoid nodule, unspecified hand
M06.351 Rheumatoid nodule, right hip
M06.352 Rheumatoid nodule, left hip
M06.359 Rheumatoid nodule, unspecified hip
M06.361 Rheumatoid nodule, right knee
M06.362 Rheumatoid nodule, left knee
M06.369 Rheumatoid nodule, unspecified knee
M06.371 Rheumatoid nodule, right ankle and foot
M06.372 Rheumatoid nodule, left ankle and foot
M06.379 Rheumatoid nodule, unspecified ankle and foot
M06.38 Rheumatoid nodule, vertebrae
M06.39 Rheumatoid nodule, multiple sites
M06.811 Other specified rheumatoid arthritis, right shoulder
M06.812 Other specified rheumatoid arthritis, left shoulder
M06.821 Other specified rheumatoid arthritis, right elbow
M06.822 Other specified rheumatoid arthritis, left elbow
M06.831 Other specified rheumatoid arthritis, right wrist
M06.832 Other specified rheumatoid arthritis, left wrist
M06.841 Other specified rheumatoid arthritis, right hand
M06.842 Other specified rheumatoid arthritis, left hand
M06.851 Other specified rheumatoid arthritis, right hip
M06.852 Other specified rheumatoid arthritis, left hip
M06.861 Other specified rheumatoid arthritis, right knee
M06.862 Other specified rheumatoid arthritis, left knee
M06.871 Other specified rheumatoid arthritis, right ankle and foot
M06.872 Other specified rheumatoid arthritis, left ankle and foot
M06.88 Other specified rheumatoid arthritis, vertebrae
M06.89 Other specified rheumatoid arthritis, multiple sites
M06.9 Rheumatoid arthritis, unspecified

Group 3

(2 Codes)
Group 3 Paragraph

It is the provider’s responsibility to select codes carried out to the highest level of specificity and selected from the ICD-10-CM code book appropriate to the year in which the service is rendered for the claim(s) submitted.

The following ICD-10-CM codes support medical necessity and provide coverage for CPT code: 81595-CARDIOLOGY ALLOMAP.

Group 3 Codes
Code Description
Z48.21 Encounter for aftercare following heart transplant
Z94.1 Heart transplant status
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ICD-10-CM Codes that DO NOT Support Medical Necessity

Group 1

Group 1 Paragraph

All those not listed under the “ICD-10 Codes that Support Medical Necessity” section of this article.

Group 1 Codes

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ICD-10-PCS Codes

Group 1

Group 1 Paragraph

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Group 1 Codes

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Additional ICD-10 Information

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Bill Type Codes

Contractors may specify Bill Types to help providers identify those Bill Types typically used to report this service. Absence of a Bill Type does not guarantee that the article does not apply to that Bill Type. Complete absence of all Bill Types indicates that coverage is not influenced by Bill Type and the article should be assumed to apply equally to all claims.

Code Description

Please accept the License to see the codes.

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Revenue Codes

Contractors may specify Revenue Codes to help providers identify those Revenue Codes typically used to report this service. In most instances Revenue Codes are purely advisory. Unless specified in the article, services reported under other Revenue Codes are equally subject to this coverage determination. Complete absence of all Revenue Codes indicates that coverage is not influenced by Revenue Code and the article should be assumed to apply equally to all Revenue Codes.

Note: The contractor has identified the Bill Type and Revenue Codes applicable for use with the CPT/HCPCS codes included in this article. Providers are reminded that not all CPT/HCPCS codes listed can be billed with all Bill Type and/or Revenue Codes listed. CPT/HCPCS codes are required to be billed with specific Bill Type and Revenue Codes. Providers are encouraged to refer to the CMS Internet-Only Manual (IOM) Publication 100-04, Medicare Claims Processing Manual, for further guidance.


Code Description

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Other Coding Information

Group 1

Group 1 Paragraph

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Group 1 Codes

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Coding Table Information

Excluded CPT/HCPCS Codes - Table Format
Code Descriptor Generic Name Descriptor Brand Name Exclusion Effective Date Exclusion End Date Reason for Exclusion
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Non-Excluded CPT/HCPCS Ended Codes - Table Format
Code Descriptor Generic Name Descriptor Brand Name Exclusion Effective Date Exclusion End Date Reason for Exclusion
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Revision History Information

Revision History Date Revision History Number Revision History Explanation
08/03/2022 R5

Article revised and published on 11/17/2022 effective for dates of service on and after 08/03/2022 in response to an inquiry. The following codes have been added to the ‘ICD-10-CM Codes that Support Medical Necessity’ section under ‘Group 2 Codes’: M05.00, M05.019, M05.029, M05.039, M05.049, M05.059, M05.069, M05.079, M05.10, M05.119, M05.129, M05.139, M05.149, M05.159, M05.169, M05.179, M05.20, M05.219, M05.229, M05.239, M05.249, M05.259, M05.269, M05.279, M05.30, M05.319, M05.329, M05.339, M05.349, M05.359, M05.369, M05.379, M05.40, M05.419, M05.429, M05.439, M05.449, M05.459, M05.469, M05.479, M05.50, M05.519, M05.529, M05.539, M05.549, M05.559, M05.569, M05.579, M05.60, M05.619, M05.629, M05.639, M05.649, M05.659, M05.669, M05.679, M05.70, M05.719, M05.729, M05.739, M05.749, M05.759, M05.769, M05.779, M05.9, M06.00, M06.019, M06.029, M06.039, M06.049, M06.059, M06.069, M06.079, M06.20, M06.219, M06.229, M06.239, M06.249, M06.259, M06.269, M06.279, M06.30, M06.319, M06.329, M06.339, M06.349, M06.359, M06.369, M06.379, and M06.9. A coding expectation was added to the ’Article Guidance’ section and these unspecified codes were added since performance of the service is not reliant on the location. A section titled ‘Documentation Requirements’ has been added, along with formatting changes throughout the article.

12/12/2021 R4

Article revised and published on 12/09/21 effective for dates of service on and after 12/12/21 in response to the new Pharmacogenomic LCD/LCA becoming effective. All CPT codes that are in the Pharmacogenomic LCA have been removed from this article. The following codes have been removed from the ‘CPT/HCPCS Codes’ Group 1 Codes: 81225, 81226, 81227, 81355, 81374, 81377, 81381 and 81383. The ‘ICD-10-CM Codes that Support Medical Necessity’ section has been revised to remove Group 1 Codes for 81225 and Group 2 Codes for 81226. The remaining Groups were renumbered accordingly.

07/01/2020 R3

Article revised and published on 06/25/2020 effective for dates of service on and after 07/01/2020 as a non-discretionary update to remove the Germline Mutation CPT Code Table, Group 2 CPT/HCPCS Code Paragraph and the associated codes have been removed. CPT codes 81227 and 81355 have been placed into CPT Code Group 1. Group 3 CPT Code Paragraph regarding noncovered CPT codes, and Group 3 CPT/HCPCS Codes have been removed. These services will now be covered when provided according to the LCD consistent with CMS direction.

02/13/2020 R2

Article revised and published on 02/13/2020 effective for dates of service on and after 10/28/2019. The following ICD-10-CM codes have been added to the Group 3 codes: I81, I82.0, I82.1, I82.210, I82.211, I82.220, I82.221, I82.290, I82.291, I82.3, I82.401, I82.402, I82.403, I82.411, I82.412, I82.413, I82.421, I82.422, I82.423, I82.431, I82.432, I82.433, I82.441, I82.442, I82.443, I82.451, I82.452, I82.453, I82.461, I82.462, I82.463, I82.491, I82.492, I82.493, I82.4Y1, I82.4Y2, I82.4Y3, I82.4Z1, I82.4Z2, I82.4Z3, I82.501, I82.502, I82.503, I82.511, I82.512, I82.513, I82.521, I82.522, I82.523, I82.531, I82.532, I82.533, I82.541, I82.542, I82.543, I82.551, I82.552, I82.553, I82.561, I82.562, I82.563, I82.591, I82.592, I82.593, I82.5Y1, I82.5Y2, I82.5Y3, I82.5Z1, I82.5Z2, I82.5Z3, I82.601, I82.602, I82.603, I82.611, I82.612, I82.613, I82.621, I82.622, I82.623, I82.701, I82.702, I82.703, I82.711, I82.712, I82.713, I82.721, I82.722, I82.723, I82.A11, I82.A12, I82.A13, I82.A21, I82.A22, I82.A23, I82.B11, I82.B12, I82.B13, I82.B21, I82.B22, I82.B23, I82.C11, I82.C12, I82.C13, I82.C21, I82.C22, I82.C23, I82.811, I82.812, I82.813, I82.890.

11/07/2019 R1

Article revised and published on 11/07/2019. System changes have been made to our articles in response to CMS Change Request 10901. The Coding Section has been reordered and new sections for CPT/HCPCS Modifiers and Other Coding Information have been added.

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Associated Documents

Medicare BPM Ch 15.50.2 SAD Determinations
Medicare BPM Ch 15.50.2
Related National Coverage Documents
NCDs
90.1 - Pharmacogenomic Testing for Warfarin Response
SAD Process URL 1
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SAD Process URL 2
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Statutory Requirements URLs
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Rules and Regulations URLs
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CMS Manual Explanations URLs
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Other URLs
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Public Versions
Updated On Effective Dates Status
01/19/2024 01/01/2024 - N/A Currently in Effect View
11/11/2022 08/03/2022 - 12/31/2023 Superseded You are here
Some older versions have been archived. Please visit the MCD Archive Site to retrieve them.

Keywords

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