Clinical Labs Information Center
Access the Medicare Clinical Laboratory Fee Schedule (CLFS) for current payment rates on covered laboratory tests. Find annual fee schedule updates, HCPCS coding information, private payor data reporting requirements, and resources for applicable clinical laboratories billing under Medicare Part B.
Announcements
Latest News
The CLIA Program and Medicare Laboratory Services (PDF) is designed to provide education on CLIA test methods categorized, enrollment In the CLIA program, types of certificates, certificate compliance and performance measures, and certificate of accreditation.
Resources
Enrollment & Participation
- Medicare Provider-Supplier Enrollment
- Enrollment Applications
- Conditions for Coverage (CfCs) and Conditions of Participation (CoPs)
- Information for Medicare providers for the National Provider Identifier (NPI) Standard
Coverage
- Medicare Coverage - General Information
- National Coverage Determinations (NCD) Manual - Pub. 100-03
- Lab NCDs - ICD-9
- Lab NCDs - ICD-10
Program Manuals & Transmittals
- Medicare Claims Processing Manual, Chapter 16: Laboratory Services (PDF)
- Medicare Benefit Policy Manual, Chapter 15, Section 80.1: Clinical Laboratory Services (PDF)
- Transmittals
Fraud & Abuse
Billing & Payment
- Clinical Laboratory Fee Schedule
- Electronic Billing & EDI Transactions - Medicare information on electronic transactions under HIPAA
- Medicare Secondary Payer
Coding
- Medicare National Correct Coding Initiative (NCCI) Edits
- HCPCS - General Information
- Alpha-Numeric HCPCS
- ICD-10
Policies, Regulations, & Legislation
Stay Informed
- Subscribe to our MLN Connects® newsletter to learn about Medicare coverage, billing, and payment updates for health care providers
- Get Medicare Learning Network® educational resources
- Visit the Newsroom for press releases and fact sheets
Contacts
- Quality Improvement Organizations (QIO)
- Contact CMS
- Find your Medicare Administrative Contractor's website
Page Last Modified:
07/01/2026 12:05 PM