Welcome to the Pharmacy and Dispensing Entity (DE) Resources page for the Medicare Drug Price Negotiation Program. Pharmacies and other dispensing entities ("dispensing entities") can use the information described below to prepare for the January 1, 2026 implementation of the Medicare Drug Price Negotiation Program, the date the negotiated maximum fair prices (MFPs), for the first ten drugs selected for negotiation covered by Part D go into effect.
MTF Data Module (DM) Enrollment is Now Open!
MTF Resources and Support
- For MTF Help Desk application and technical support, including additional resources, live chat support, and 24/7 online ticket submission, visit the MTF Help Desk
Toll-Free: 877-683-4457 (877-MTF-4HLP)
Resource examples include:
- MTF User Guide
- MTF 835 Companion Guide
- MTF Background and Enrollment Launch Event Recording
- Step-by-step Dispensing Entity Enrollment Process Video
- Step-by-step Third-party Support Entity (TPSE) Enrollment Process Video
Enrollment Timeline
MTF Enrollment Timeline
During Enrollment and Prior to January 2026, using the MTF will allow Dispensing Entities to:
- Experience a streamlined enrollment procedure if the enrolling dispensing entity chooses to rely on up to date NCPDP data;
- Self-identify as anticipating material cash flow issues as defined in section 40.4.2.2 of final guidance as applicable;
- Access helpful information on using the MTF and assign system roles;
- Instruct the MTF DM where MFP refund payments and remittance advice should be sent, including to a linked third-party support entity (TPSE) as applicable;
- Review manufacturer MFP Effectuation Plans, including plans for dispensing entities self-identifying with cash flow issues (expected this Fall)
- Review and sign MTF Agreements with CMS and their MTF contractors that will be responsible for operating the MTF
During Implementation
- Receive MFP refund payments from Primary Manufacturers who have opted in to the MTF Payment Module (MTF PM);
- Receive remittance for payment made by paper check or Electronic Remittance Advice that uses the X12 835 standard adopted under the Health Insurance Portability and Accountability Act (HIPAA) for electronic payments;
- Submit complaints or disputes;
- View reports on the status of PDE data processing through the MTF DM user interface, in order to aid in financial planning.
Human-Centered Design Activities
The MTF Human-Centered Design Team is interested in gathering dispensing entity feedback. To express interest in providing feedback about the MTF’s design and functionality, provide your information via this link, and we may follow up to gather more information.
MTF Information Collection Request (ICR)
The ICR for the Medicare Transaction Facilitator for 2026 and 2027 under Sections 11001 and 11002 of the Inflation Reduction Act (IRA) is now available. This ICR previously underwent a 60-day public comment period, concluding on December 27, 2024 and a 30-day comment period, concluding on May 1, 2025; CMS revised this ICR based on public comments and the Office of Management and Budget (OMB) has approved the finalized ICR package (OMB control number 0938-1483). The final ICR is available for viewing on OMB's website. Click "all" to see full details.
Final MTF Agreements
The Medicare Transaction Facilitator (MTF) agreements outline the responsibilities of each party that will be engaged in the MTF, a core component of implementing the Medicare Drug Price Negotiation Program. CMS has finalized the agreements based on public feedback as well as input from the MTF contractors involved in the development and operations of the MTF system. The final MTF agreements can be found here.
Fact Sheet & Frequently Asked Questions
The Pharmacy and Dispensing Entities Resources Fact Sheet and Frequently Asked Questions document details key information for pharmacies and other dispensing entities that will engage with the new MTF system, a core component of implementing the Medicare Drug Price Negotiation Program.
- Medicare Transaction Facilitator: Fact Sheet for Pharmacies and Other Dispensing Entities (PDF) (April 7, 2025)
- Medicare Transaction Facilitator: Pharmacies and Other Dispensing Entities Frequently Asked Questions (September 2025) (PDF)
Contact Us
For questions about the MTF, visit the MTF Help Desk. For general questions about the Medicare Drug Price Negotiation Program, e-mail us at IRARebateandNegotiation@cms.hhs.gov. Please sign up to receive e-mails about the Medicare Transaction Facilitator by clicking this link , entering your email address, and selecting “Medicare Transaction Facilitator” under the Center for Medicare.