Welcome to the Pharmacy and Dispensing Entity (DE) Resources page for the Medicare Drug Price Negotiation Program. On January 1, 2026, new negotiated maximum fair prices under the Medicare Drug Price Negotiation Program went into effect and the Medicare Transaction Facilitator (MTF) began operations to support drug manufacturers in effectuating these new negotiated maximum fair prices. Pharmacies and other dispensing entities ("dispensing entities") can use the information described below as a reference regarding the effectuation of the negotiated maximum fair prices.
The Medicare Transaction Facilitator Data Module (MTF DM) is Now Live!
MTF Resources and Support
- For MTF Help Desk application and technical support, including additional resources, live chat support, and 24/7 online ticket submission, visit the MTF Help Desk
Toll-Free: 877-683-4457 (877-MTF-4HLP)
Resource examples include:
- MTF Toolkit
- MTF User Guide
- MTF Readiness Checklist
- CMS 835 Companion Guide
- MTF Informational Video about the MTF's role and functionality
- Step-by-step Dispensing Entity Enrollment Process Video
- Step-by-step Third-party Support Entity (TPSE) Enrollment Process Video
MTF Enrollment
Using the MTF allows Dispensing Entities to:
- Experience a streamlined enrollment procedure if the enrolling dispensing entity chooses to rely on up to date NCPDP data;
- Self-identify as anticipating material cash flow issues as defined in section 40.4.2.2 of final guidance as applicable;
- Access helpful information on using the MTF and assign system roles;
- Instruct the MTF DM where MFP refund payments and remittance advice should be sent, including to a linked third-party support entity (TPSE) as applicable;
- Review manufacturer MFP Effectuation Plans, including plans for dispensing entities self-identifying with cash flow issues
- Review and sign MTF Agreements with CMS and their MTF contractors that will be responsible for operating the MTF
- Receive MFP refund payments from Primary Manufacturers who have opted in to the MTF Payment Module (MTF PM);
- Receive remittance for payment made by paper check or Electronic Remittance Advice that uses the X12 835 standard adopted under the Health Insurance Portability and Accountability Act (HIPAA) for electronic payments;
- Submit complaints or disputes;
- View reports on the status of PDE data processing through the MTF DM user interface, in order to aid in financial planning.
MTF Information Collection Request (ICR)
In the final ICR for the Medicare Transaction Facilitator for 2026 and 2027 under Sections 11001 and 11002 of the Inflation Reduction Act (IRA) CMS revised this ICR based on public comments and the Office of Management and Budget (OMB) has approved the finalized ICR package (OMB control number 0938-1483). The final ICR is available for viewing on OMB's website. Click "all" to see full details.
Final MTF Agreements
The final MTF agreements outline the responsibilities of each party that engaged in the MTF, a core component of implementing the Medicare Drug Price Negotiation Program. The final MTF agreements can be found here.
Fact Sheet & Frequently Asked Questions
The Pharmacy and Dispensing Entities Resources Fact Sheet and Frequently Asked Questions document details key information for pharmacies and other dispensing entities engaging with the new MTF system, a core component of implementing the Medicare Drug Price Negotiation Program.
- Medicare Transaction Facilitator: Fact Sheet for Pharmacies and Other Dispensing Entities (PDF) (April 7, 2025)
- Medicare Transaction Facilitator: Pharmacies and Other Dispensing Entities Frequently Asked Questions (December 2025) (PDF)
Contact Us
For questions about the MTF, visit the MTF Help Desk. For general questions about the Medicare Drug Price Negotiation Program, e-mail us at IRARebateandNegotiation@cms.hhs.gov. Please sign up to receive e-mails about the Medicare Transaction Facilitator by clicking this link , entering your email address, and selecting “Medicare Transaction Facilitator” under the Center for Medicare.