MTF User Resources for Manufacturers
The Medicare Transaction Facilitator User Guide is available on the MTF Help Desk site. For a step-by-step demonstration of the MTF enrollment and user management processes for manufacturers, watch this video: MTF Manufacturer Enrollment Process.
Medicare Transaction Facilitator (MTF) Agreements
The Medicare Transaction Facilitator (MTF) User Agreements outline the responsibilities of each party that will be engaged in the Medicare Transaction Facilitator, a core component of implementing the Medicare Drug Price Negotiation Program. For more information about these agreements, see the FAQs here (PDF).
- Final MTF agreements and a summary describing the public feedback received are available here:
- MTF Data Module User Agreement for Primary Manufacturers (PDF)
- MTF Payment Module User Agreement for Participating Primary Manufacturers (PDF)
- MTF Data Module User Agreement for Dispensing Entities (PDF)
- Summary of Public Feedback and CMS’ Responses on the Draft MTF Agreements (PDF)
- Public Feedback letters (PDF)
- Draft MTF agreements are available below:
Manufacturer Frequently Asked Questions (FAQ)
This FAQ resource addresses inquiries that CMS has received from Primary Manufacturers participating in the Medicare Drug Price Negotiation Program. CMS will share additional information on manufacturer-initiated claims reversals, the credit/debit ledger system, and other operational details in forthcoming FAQs and technical instructions. The FAQ document is available here (PDF).
MTF Information Collection Request
The ICR for the Medicare Transaction Facilitator for 2026 and 2027 under Sections 11001 and 11002 of the Inflation Reduction Act (IRA) is available for viewing on OMB's website (OMB control number 0938-1483). Click "all" to see full details.
The Manufacturer MFP Effectuation Plan Form template is available at the following link: MFP Effectuation Plan Form Template (PDF).
MTF Interface Control Documents (ICDs)
The Medicare Transaction Facilitator Data Module (MTF DM) is the system through which drug manufacturers participate in the Medicare Drug Price Negotiation Program. The MTF DM facilitates the secure exchange of data between CMS, drug manufacturers and dispensing entities. The ICDs included in this section define the data elements used in MTF claims and claim payments.
MTF Manufacturer Data Exchange Technical Documentation
This document provides technical specifications, security requirements and procedural guidance for drug manufacturers using the Medicare Transaction Facilitator (MTF) Data Module (DM), including instructions for Amazon Web Services (AWS) S3 for file exchange. The document is available here (PDF).
MTF Manufacturer Refund Notice (MRN), Manufacturer Refund Advice (MRA), and Manufacturer Refund Receipt (MRR) ICD
The MRN, MRA, and MRR data are included within a single file exchanged between the MTF DM system and drug manufacturers, as frequently as daily.
The MRN portion communicates refund information from the MTF DM to drug manufacturers, including the amount due based on the calculated Standard Default Refund Amount (SDRA) if a Wholesale Acquisition Cost (WAC) is available. Drug manufacturers process the MRN data and return the file to the MTF DM system with the completed MRA section within 14 days.
The MRA portion includes remittance instructions from the drug manufacturer to the MTF DM system regarding the correct payment amounts (if applicable) to be distributed. The MTF DM system then transmits instructions to the MTF Payment Module (MTF PM) for remittance to dispensing entities.
The MRR portion provides a notice to the Primary Manufacturer that acknowledges receipt and processing of MRA elements (also referred to as the claim-level payment elements) by the MTF DM. For MFP refund payments facilitated through the MTF PM, the fill includes information on MFP refund payment status, payment amounts, and the application of any credits when applicable.